I am professor of clinical epidemiology at the University of Bristol, UK. I lead a research programme investigating cancer aetiology, early-detection and prognosis. My work exploits the application of causal analysis methods in cancer epidemiology. I established CRUK’s Integrative Cancer Epidemiology Programme (ICEP) at Bristol University. ICEP combines cutting-edge genomic technologies, novel systematic review methods and large-scale bioinformatic platforms to robustly identify novel cancer risk-factors, molecular mechanisms and predictive biomarkers.